Subjective and Objective Cognitive Deficits in Patients with Post-COVID Syndrome A Challenge for Neuropsychologists

Cognitive impairment is a prominent symptom of the post-COVID syndrome (PCS). However, the correspondence between subjective cognitive complaints (SCC) and objective results is inconsistent. Here, we investigated this discrepancy. This longitudinal study included N = 42 individuals who reported SCC as PCS after mild infection at inclusion. Data collection comprised questionnaires and neuropsychological assessment at baseline and follow-up (FU). At FU - on average 15 months after acute COVID-19 - 88 % of patients reported persisting SCC. There was an approx. 40 % discrepancy between subjective report and test results at both visits. Patients with SCC and objective impairment indicated elevated fatigue and reduced quality of life compared to patients without SCC at FU. A growing number of patients is anticipated to request neuropsychological assessments even after mild infections.

Critical Commentary: Beyond growth and density: Recentring the demographic drivers of urban health and risk in the global south

Debates within urban studies concerning the relationship between urbanisation and infectious disease focus on issues of urban population growth, density, migration and connectivity. However, an effective long-term risk and wellbeing agenda, without which the threat of future pandemics cannot be mitigated, must also take account of demographic forces and changes as critical drivers of transmission and mortality risk within and beyond cities. A better understanding of the dynamics of fertility, mortality and changing age structures – key determinants of urban decline/growth in addition to migration – provides the foundation upon which healthier cities and a healthy global urban system can be developed. The study of how basic demographic attributes and trends are distributed in space and how they interact with risks, including those of infectious disease, must be incorporated as a priority into a post-COVID-19 urban public health agenda. This perspective concurs with recent debates in urban studies emphasising the demographic drivers of urban change. Moreover, it raises critical questions about the microbial and environmental emphasis of much research on the interface of urban health and governance.

eDNA testing reveals surprising findings on fish population dynamics in Thailand.

COVID-19, a global health concern, has an effect on all aspects of the economy. The aquaculture and fishing industries were severely harmed as a result of the closures in multiple nations. Regular systems for inventory monitoring, production, and supply were disrupted. Cancellation of programmes for research, fieldwork, sampling, and tagging influences management-required data. For effective species management, fish dispersion assessments are indispensable. However, due to the difficulty of accessing sampling sites and the associated costs, there is frequently a lack of comprehensive information regarding the distribution and abundance of organisms. The COVID-19 prohibition made fish monitoring more problematic. Due to constant pressure, populations of the stone lapping minnow (Garra cambodgiensis), one of Thailand's overfished fish, are rapidly declining. Therefore, eDNA-based monitoring was devised and implemented to reveal the likely dispersal of the species in Thailand prior to and following the lockdown. At 28 locations within the Chao Phraya River Basin, water samples were collected. qPCR was used to determine the presence or absence of G. cambodgiensis in water samples. In 78 of 252 water samples, a wide range of computed copy numbers for G. cambodgiensis eDNA was observed. It was discovered that samples collected in 2021 (after the lockdown) contain a higher concentration of G. cambodgiensis eDNA than samples collected in 2018 or 2019 (prior to the lockdown). The closure appears to be a boon and may result in a substantial restocking of the fish we have studied. Overall, eDNA-based analysis is an extremely promising new survey instrument.

The Impact of the COVID-19 Pandemic on People With Cognitive Impairment Residing in Aged Care Facilities: An Integrative Review.

This review explored the impact of the COVID-19 pandemic on people with cognitive impairment living in aged care facilities. It also considered policy and organizational responses to COVID-19, and makes recommendations to ameliorate the impact of the pandemic on residents with cognitive impairment in aged care facilities. ProQuest, PubMed, CINAHL, Google Scholar, and Cochrane Central were searched April-May 2022 for peer reviewed articles, and an integrative review of reviews was conducted. Nineteen reviews were identified which referred to people with cognitive impairment living in residential aged care facilities (RACFs) during COVID-19. Negative impacts were highlighted, including COVID-19 related morbidity and mortality, social isolation, and cognitive, mental health and physical decline. Few research articles and policy responses consider people with cognitive impairment in residential aged care. Reviews highlighted that social engagement of residents should be better enabled to reduce the impact of COVID-19. However, residents with cognitive impairment may have inequitable access to communications technology for the purposes of assessment, health care and social engagement, and require more support (along with their families) to access this technology. Greater investment in the residential aged care sector (eg, for workforce and training) is required to address the significant impacts of the COVID-19 pandemic on people with cognitive impairment.

Tourists, selfies and coastal monitoring during COVID-19

Citizen science in coastal ecosystems often involve (eco-)tourists that actively monitor reefs, species and pollution. Data collected by tourists, passively, was used to gain insight into landings of the largest fish, the whale shark (Rhincodon typus), in Pangandaran Bay, Indonesia. Monitoring of illegal fishing was halted due to COVID-19 travel restrictions and lockdowns. With two million, mainly Indonesian, tourists visiting Pangandaran Bay in 2020 (30% less than in 2019) enough tourists were present to record landings of whale sharks. Monitoring social media revealed reports of 10 whale shark landings between August 2020 and August 2022. Seven were in July-August of immatures 6-7 m in length. The information passively provided by tourists since COVID-19 have given insights into the biology of whale sharks, landing risks and how communities interact with sharks. Feeding back this information to tourists is challenging, yet vital, to cement a sense of belonging, purpose and attachment to their holiday location.

Those Above Poverty Line: Development and Vulnerability to the Pandemic

COVID-19 pandemic has posed severe challenges to human security with unprecedented vulnerabilities to food, health and income insecurities. In India, as elsewhere, interventions to redress these insecurities have focused on the most vulnerable, those who are extremely poor and fall below the poverty line. This chapter looks at a section of people who are not the extreme poor but nevertheless experience food, health and income insecurity. This group lies just above the poverty line, are excluded from usual welfare targeting and benefits provided by the state, and, represents the gains of development interventions over the past two to three decades. The pandemic has adversely impacted the livelihoods of this group and sent them into a downward spiral of decline into poverty with economic and psychological consequences. The trauma of decline impacts the psychological resilience of these individuals. From a policy perspective, arresting such decline into poverty requires a dynamic and emergent classification of population to target relief interventions at these groups as they are invisible in routine and static categories of welfare targeting. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer 2022.

Local perception of the current state and threat factors of a critically endangered species, Celtis toka (Forssk.) Hepper & JRI Wood, in Burkina Faso: implications for species conservation

Celtis toka, the only species of the genus Celtis (family Cannabaceae) encountered in the flora of Burkina Faso, is critically endangered in the country. To engage the public for the future conservation and domestication of the species, knowledge of the factors threatening Celtis toka survival is necessary. Thus, the study objective was to identify the perceptions of local people concerning the current state and conservation strategies of Celtis toka in Burkina Faso. To investigate potential solutions to the threats posed to Celtis toka, we randomly surveyed 405 consenting participants using a selected semi-structured interview. Moreover, field observations were performed to assess the threat drivers cited by local people of the Sudanian and Sudano-Sahelian climatic zones. Descriptive analyses (relative frequency and fidelity level) and generalized linear models (GLMs) were used to highlight the impact of sociodemographic factors and climate zones on the current state, threat drivers, and potential solutions. The chi-square test was used to assess whether to plant C. toka. GLM analyses revealed that local knowledge about the current state, threat factors and potential solution to the threat as related to natural stand varied significantly according to ethnolinguistic group (P < 0.000), sex (P = 0.01) and age (P = 0.01). Rural people had varying perceptions of the current state of C. toka. Sixty-eight percent reported a decrease in population, ten percent reported scarcity, and five percent reported extinction. The views of local people were that the factors affecting C. toka were pruning (25%), climate change (14%), deforestation (10%), ageing (10%), debarking (9%), and agriculture (7%). Potential solutions included planting (45%), conservation of C. toka and its habitat (27%), sustainable use of Celtis toka (14%), promotion of education and awareness about Celtis toka (10%) and tree/crop association (5%). The study concluded that the ethnobotanical knowledge of Celtis toka may play an important role in its conservation and domestication in Burkina Faso. Furthermore, its incorporation into reforestation and restoration programs is critical to species survival.

Fertility and Reproductive Attitudes of the Population Before and After the Epidemiological Situation Worse

Introduction. The preservation and growth of the population is a key task of the Russian Federation Demographic Policy Concept until 2025. Nevertheless, in recent years, the achievement of this task has been difficult due to escalation of socio-economic and demographic problems. The purpose of the article is to determine and compare birth rates and reproductive attitudes of the population in various periods after the beginning of the 2000s, which differ in the socio-economic context and the list of demographic policy measures, including under the latest circumstances - the worsening epidemiological situation. Materials and Methods. The study is based on a statistical analysis of time series data indicators for conditional generations that reflect the demographic situation of fertility in Russia and the Komi Republic - crude and total fertility rates, natural population growth (decline), the number of women in reproductive age (15-49 years) in total structure of the female population, the number of women aged 15-24 in the structure of the female population of reproductive ages. Also, the methodological basis of the presented work is based on the results of three sociological studies, conducted by a team of scientists of The Institute for Social Economic and Energy problems of the North of the North Federal Research Center Komi Science Centre UB RAS in 2008, 2013 and 2020 among the population of the Komi Republic. Results. It is revealed that the most successful period of demographic development in Russia was 2013-2016 and in the Komi Republic in 2011-2016, which consists in achieving natural population growth. Further, there was a decrease in the birth rate. It is determined that the situation in the field of population reproduction has worsened in the context of the COVID-19 pandemic in Russia and the Komi Republic. The study reveals that reproductive attitudes in all generations are the best in 2013. The significant success in this period is the growth of reproductive attitudes even among young cohorts. Further in 2020, the expected number of children decreased in all age cohorts. In 2020, the pattern remains - the lowest reproductive orientations are in the two youngest age cohorts of 1996-2000 and 2001-2005 birth. Discussion and Conclusion. The main result of the work was the confirmation on the example of the northern region of Russia the thesis that the growth of the standard of living is accompanied by an increase in the reproductive attitudes of the population and the birth rate, and vice versa. From a theoretical point of view, the usefulness of the article lies in the description of the processes of fertility and the dynamics of the reproductive attitudes of the population, taking into account the changing socio-economic and epidemiological conditions. From a practical point of view, the information obtained can be useful as an assessment of future fertility prospects and confirmation of the high role of the socioeconomic well-being of the population in addressing the issue of increasing the level of children in the families.

Reproductive intentions of Russians with children at the beginning of COVID-19 pandemic

The paper studies the reproductive intentions of the Russians who already have at least one child before and during the quarantine restrictions (lockdowns) due to COVID-19. Binary choice logistic models and a set of machine learning models were evaluated on the data from the Person, Family, Society survey conducted in March-May 2020. Modeling of the respondents ' intentions to have more children in the short term (3 years) and the long term (more than 3 years) showed that external shocks such as the COVID-19 pandemic and the strict quarantine regulations associated with it had an impact on fertility intentions, but only in the short term. These external shocks were less significant than such factors as age of the respondent;the number of children already born;availability of housing needed to expand the family;the maternity capital program availability, which includes the opportunity to improve housing conditions after the birth of children. As Russians with children showed the increase of the probability of having additional children after April 2020, we conclude that the effect of COVID-19 on reproductive intentions was acyclical. The estimation of models with heterogeneous effects showed that the pandemic had a stronger impact on respondents with above-average household incomes.

Coronovirus Covid-19 Like a Trigger of Sovereignization

Pandemic of COVID-19 has already become a historical event, aftermath of which revealed the disability of suprastate institutions and international organizations to take flash decisions in order to save life of an average person. These circumstances determined the aim of the article to unite theoretical and applied researches of interdependence between emergency situations and sovereignization. It has been determined that the common trait of these practices is the decline of democratic freedoms and processes because of life values reappraisal. The article also considers the reasons of reconstruction of neopatrimonialism in post-soviet countries during the Pandemic.

The associations between cognitive function and depressive symptoms among older Chinese population: A cohort study.

With the rapid development of society, population aging has emerged as a significant global challenge. This study aimed to evaluate the impact of baseline cognitive performance, current cognitive function, and cognitive decline on subsequent depressive symptoms. Data were obtained from participants aged 65 years and older in the Chinese Longitudinal Healthy Longevity Survey (CLHLS), Wave 2014-2018. Of the 7,192 participants in Wave 2014, 1,627 were included in the analysis. Multivariate regressions were conducted to estimate the associations between cognitive measures and depressive symptoms. Our results indicated that baseline cognitive function was not associated with subsequent depressive symptoms, but current cognitive function was. Furthermore, participants who experienced significant cognitive decline were more likely to develop depressive symptoms. Covariates, including marital status, economic status, physical activity, and recreational activity, were also associated with subsequent depressive symptoms. These findings suggest that slowing cognitive decline is an effective strategy for preventing depressive symptoms in older adults, promoting their health and wellbeing.

Factors Predicting Compliance with the Uptake of the Third COVID-19 Vaccine among the Arab Minority in Israel

Between December 2020 and February 2021, Israel administered two doses of COVID-19 vaccine to >50% of its adult population. Nonetheless, due to declining immunity and the spread of the COVID-19 delta variant, the government offered a third COVID-19 vaccine dose in July 2021. Although the vaccine was shown to provide effective protection against severe illness, the compliance rate among the Arab minority remained low. The present study sought to identify the factors predicting willingness to uptake the COVID-19 vaccine in the Arab community. An online survey of 2486 participants was conducted in November 2021 to assess vaccination-related behaviours, such as perceived benefits, barriers, incentives (e.g., the green pass), subjective norms, and pandemic fatigue. Positive correlations were found among reasons for obtaining a green pass, trust in formal authorities, perceived effectiveness of the third COVID-19 vaccine dose, subjective norms, and attitudes toward the booster dose. Pandemic fatigue was positively correlated with vaccination barriers. Trust in authorities, perceived booster dose effectiveness, subjective norms, and attitudes were negatively related to pandemic fatigue and barriers to vaccination. Demographic variables such as age, education level, and income level were positively related to odds of getting the booster. Participants who reported being religious exhibited a lower rate of booster dose compliance than secular participants. The study findings show that the reasons for acquiring a green pass were positively correlated with the perceived effectiveness of the booster dose, demonstrating that individuals understood the vaccine benefits. Further, having a green pass was negatively related to barriers. Incentives such as the green pass play a major role in encouraging the population to take the COVID-19 vaccine. In addition, public campaigns to explain the health benefits and refute erroneous myths support higher vaccination rates.

Beyond the crisis: fertility variations and the family policies in the Portuguese municipalities

In a profound ageing context, such as the Portuguese, fertility becomes a key variable for the analysis of population dynamics, with increased importance given the very low levels recorded in the country. According to INE [2020], Portugal has a total fertility rate (TFR) of 1.40 children per woman, one of the lowest in the EU [Eurostat, 2022]. The economic and financial crisis of 2008 and the Troika intervention (European Commission, European Central Bank, and the International Monetary Fund, the three authorities that monitored international bailout programs) in 2011, had impacted on the socioeconomic conditions of the Portuguese population, with repercussions in other behaviors as well as in fertility. Thus, the childbearing postponement led the TFR to fall to its lowest levels on record, reaching 1.21 children per woman in 2013. Although the economic recovery has allowed a slight recovery in fertility levels, the new crisis caused by COVID-19 was reflected in a new historic decline in births in the country in 2021, when the number of live births fell below 80 000, a decrease of 8% compared to 2019 [INE, 2022]. Although this downward trend is common to almost all developed European countries [Aassve et al., 2020;Aassve et al., 2021], for Portuguese society it is a new wake-up call and a cause for concern given the population decline confirmed in the provisional data release from the 2021 Population Census (-2.1% compared to 2011). However, fertility patterns are not uniform, as they involve regional heterogeneity, which highlights a multiplicity of factors and behavioral patterns. This paper aims to approach fertility from a regional perspective to distinguish the diversity of patterns across the territory in the last two decades, and to discuss the extent to which the crises were a point of change or reinforcement of the transformations that were taking place. In the analysis, in addition to the framework and contextualisation of fertility trends by NUTS 3, the policy responses that have emerged at a local/municipal scale will be analysed. Although the crisis has contributed to the fertility decline in Portugal, its decline goes beyond the crisis reflecting changes in behavioral patterns and social and economic constraints. Thus, there persist constraints in the population dynamics that have prevented the reversal or mitigation of the decline in the inland territories that currently are also felt at the country level. © 2022 Authors. All rights reserved.

Association of Anxiety and Depression with Objective and Subjective Cognitive Decline in Outpatient Healthcare Consumers with COVID-19: А Cross-Sectional Study

Background: In addition to the neurological complications affecting people infected with COVID-19, cognitive impairment symptoms and symptoms of anxiety and depression remain a frequent cause of complaints. The specificity of cognitive impairment in patients with COVID-19 is still poorly understood. AIM: An exploratory study of factors that may be associated with cognitive decline during the COVID-19 pandemic. MEtHODs: The cross-sectional multicentre observational study was conducted in a polyclinic unit in Saint Petersburg and in the regions of the North-Western Federal Region. During the study, socio-demographic parameters and information about the somatic condition of patients who applied for primary health care was collected. Emotional and cognitive state were investigated using the Hospital Anxiety and Depression Scale (HADS) and Montreal Cognitive Assessment (MoCA). Mathematical and statistical data processing was carried out using SPSS and RStudio statistical programs. rEsULts: The study included 515 participants, 60% (n=310) of which were women. The sample was divided into those who did (28.5%, n=147) and did not (71.4%, n=368) complain of cognitive decline. Patients with complaints of cognitive decline were significantly older, had lower levels of education and higher levels of depression and anxiety according to HADS (p <0.05). Patients with complaints of cognitive decline underwent the MoCA test (24.3%, n=125). The median MoCA test scores were within the normal range (Median=27, Q1=25, Q3=28), and cognitive decline (MoCA less than 26 points) was detected in 40% (n=50) of patients with complaints of cognitive decline. No significant correlations were found between the MoCA scores and the levels of anxiety and depression according to the HADS (p >0.05). Patients with mild severity of the COVID-19 course were more successful with MoCA subtests than patients with moderate and severe courses. CONCLUSION: We found no linear association between objective cognitive deficit and the affective state of respondents. Patients' subjective complaints about cognitive dysfunction were mostly caused by their emotional state than an objective decrease of their cognitive functions. Therefore, in case of subjective complaints on cognitive decline, it is necessary to assess not only the cognitive but also the affective state of the patient. The severity of the COVID-19 course affects the functions of the cognitive sphere, including attention, regulatory functions and speech fluency. Mild and moderate severity of the COVID-19 correlates with clinically determined depression. The absence of this relationship with the severe course of the disease is probably explained by the significant somatic decompensation of patients. © 2022, Eco-Vector LLC. All rights reserved.

Macroeconomics and health: Understanding the impact of a declining economy on health outcomes of children and young adults in South Africa.

Background: The current covid-19 economic crisis continues to weaken economic growth in South Africa. This study was designed to show how a declining economic state affects the mental health conditions, metabolic risk factors, communicable conditions, and non-communicable conditions of adolescent (18-year cohorts) and adult (25-year cohorts) population groups comparatively. Study design: This was a panel analysis using secondary data issued by Statistic South Africa. Methods: The author used a Two-stage Least Squared Model (2SLS) to quantify the impact of the declining economy on mental health conditions (depression and traumatic stress), non-communicable conditions (cancer and diabetes), metabolic risk factors (alcohol abuse and hypertension), and communicable conditions (influenza, diarrhea, dry cough) of both adolescent and young adult population groups. Each group comprised a treatment and a control group. Results: The declining economic state of 2008-2014 worsens the mental health conditions, metabolic risk factors, and non-communicable conditions of adolescent and young adult populations. However, the declining economy reduced cases of communicable conditions. The impact of the declining economy worsens mental health conditions, metabolic risk factors, and non-communicable conditions more in urban settings than in rural regions. Men abuse alcohol more than women during economic decline, triggering worsening mental health conditions, hypertension, and non-communicable conditions, especially in the adult population residing in urban settings. Conclusions: Economic decline worsen mental health conditions, metabolic risk factors, and non-communicable conditions. The South African government may want to prioritize these conditions as covid-19 economic shocks continue to backslide economic growth.

Association between serologically confirmed COVID-19 infection and cognitive functioning in community dwelling older adults.

Introduction: COVID-19 infection can impact the central nervous system, and is often associated with cognitive decline. However, there are no studies linking serologically confirmed COVID-19 infection with objectively assessed cognitive functioning. We explored whether presence of SARS-CoV-2 antibodies account for variability in participants' scores on a neuropsychological assessment. Methods: In this cross-sectional study participants were 657 (mean age = 72.97; SD = 6.07 years; women = 47.7%) individuals randomly selected from the general population of the canton of Zurich and included in the Corona Immunitas study. We conducted serological tests between October 2020 and May 2021 to detect and quantify SARS-CoV-2 antibodies in peripheral venous blood samples. We assessed cognitive function, vaccination status (vaccinated; not vaccinated), number of health conditions, and demographic variables between January and August 2021. We studied the association between seropositivity and global cognitive function and five cognitive domains (language expression, language comprehension, temporal orientation, spatial orientation, and memory) with linear regression models. Based on SARS-CoV-2 antibodies and vaccination status, we stratified participants into three groups: No SARS-CoV-2 antibodies (N = 402); SARS-CoV-2 antibodies due to vaccination (N = 218); history of SARS-CoV-2 infection and no vaccination (N = 37). Results: In the regression model adjusted for age, sex, educational level, and number of health conditions, compared to those without SARS-CoV-2 antibodies, those with SARS-CoV-2 antibodies due to vaccination had better global cognitive functioning (Standardized beta = 0.10; 95% CI = 0.02; 0.17), and those with SARS-CoV-2 antibodies due to infection had poorer cognitive functioning (Standardized beta = -0.10; 95% CI = -0.18; -0.03). Regarding cognitive domains, compared to those without SARS-CoV-2 antibodies, those with SARS-CoV-2 antibodies due to infection scored more poorly on language comprehension and temporal orientation, and those with SARS-CoV-2 antibodies due to vaccination scored better on memory. Discussion: By linking serologically confirmed presence of SARS-CoV-2 antibodies to poorer global cognitive functioning in community dwelling older adults we strengthen existing evidence in support of cognitive decline related to COVID-19. Given the large number of infected older adults, and the endurance of the pandemic, our results highlight the need to address COVID-19 related cognitive decline in the clinical and public health areas of prevention, diagnosis, and treatment.

The Contribution of Environmental Science to Mental Health Research: A Scoping Review.

Mental health is influenced by multiple complex and interacting genetic, psychological, social, and environmental factors. As such, developing state-of-the-art mental health knowledge requires collaboration across academic disciplines, including environmental science. To assess the current contribution of environmental science to this field, a scoping review of the literature on environmental influences on mental health (including conditions of cognitive development and decline) was conducted. The review protocol was developed in consultation with experts working across mental health and environmental science. The scoping review included 202 English-language papers, published between 2010 and 2020 (prior to the COVID-19 pandemic), on environmental themes that had not already been the subject of recent systematic reviews; 26 reviews on climate change, flooding, air pollution, and urban green space were additionally considered. Studies largely focused on populations in the USA, China, or Europe and involved limited environmental science input. Environmental science research methods are primarily focused on quantitative approaches utilising secondary datasets or field data. Mental health measurement was dominated by the use of self-report psychometric scales. Measures of environmental states or exposures were often lacking in specificity (e.g., limited to the presence or absence of an environmental state). Based on the scoping review findings and our synthesis of the recent reviews, a research agenda for environmental science's future contribution to mental health scholarship is set out. This includes recommendations to expand the geographical scope and broaden the representation of different environmental science areas, improve measurement of environmental exposure, prioritise experimental and longitudinal research designs, and giving greater consideration to variation between and within communities and the mediating pathways by which environment influences mental health. There is also considerable opportunity to increase interdisciplinarity within the field via the integration of conceptual models, the inclusion of mixed methods and qualitative approaches, as well as further consideration of the socio-political context and the environmental states that can help support good mental health. The findings were used to propose a conceptual model to parse contributions and connections between environmental science and mental health to inform future studies.

The threat of COVID-19 to the conservation of Tanzanian national parks.

In many low-income countries, the conservation of natural resources in protected areas relies on tourism revenue. However, tourist numbers in Africa were severely reduced by the COVID-19 pandemic, thus, putting the conservation of these important protected areas at risk. We use records from gate passings at national parks across Tanzania to demonstrate the immediate and severe impact on tourist numbers and revenues resulting from the COVID-19 pandemic and associated restrictions, and whether international and local (East African) tourists were affected equally. We discuss mechanisms that may reduce future negative impacts of sudden loss of revenue from international tourism, such as increasing the revenue portfolio and thereby decrease the dependency on revenues from international tourists. More important, we encourage local governments, national park authorities, and the world community to further develop and initiate external funding options to reduce the dependency on income from international nature-based tourism to preserve national parks and biodiversity. An additional long-term goal for ensuring sustained conservation would be to increase benefits to local communities adjacent to national parks, encouraging local involvement and thereby reducing the dependence on external funding in the future.

Meta-analysis of age-related cognitive decline reveals a novel locus for the attention domain and implicates a COVID-19-related gene for global cognitive function.

INTRODUCTION: Cognitive abilities have substantial heritability throughout life, as shown by twin- and population-based studies. However, there is limited understanding of the genetic factors related to cognitive decline in aging across neurocognitive domains. METHODS: We conducted a meta-analysis on 3045 individuals aged ≥65, derived from three population-based cohorts, to identify genetic variants associated with the decline of five neurocognitive domains (attention, memory, executive function, language, visuospatial function) and global cognitive decline. We also conducted gene-based and functional bioinformatics analyses. RESULTS: Apolipoprotein E (APOE)4 was significantly associated with decline of memory (p = 5.58E-09) and global cognitive function (p = 1.84E-08). We identified a novel association with attention decline on chromosome 9, rs6559700 (p = 2.69E-08), near RASEF. Gene-based analysis also identified a novel gene, TMPRSS11D, involved in the activation of SARS-CoV-2, to be associated with the decline in global cognitive function (p = 4.28E-07). DISCUSSION: Domain-specific genetic studies can aid in the identification of novel genes and pathways associated with decline across neurocognitive domains. HIGHLIGHTS: rs6559700 was associated with decline of attention. APOE4 was associated with decline of memory and global cognitive decline. TMPRSS11D, a gene involved in the activation of SARS-CoV-2, was implicated in global cognitive decline. Cognitive domain abilities had both unique and shared molecular pathways across the domains.